A 75-year-old man presents to the office for evaluation of new symptoms. He has a history of cancer and takes chemotherapeutic treatment. Now he complains of dyspnea and mild fatigue since last week. Examination reveals temperature of 98.3 F, pulse of 80/min, blood pressure of 140/86 and respiratory rate of 22/min. On chest auscultation, there are crackles on both lung bases with no wheezes. A chest x-ray shows bilateral diffuse interstitial markings.
Which of the following agents is responsible for this patient’s new features?
A- Bleomycin
B- Cisplatin
C- Cyclophosphamide
D- Etoposide
E- Paclitaxel
Answer
Bleomycin is the only drug of the above list that causes pulmonary fibrosis. It is age- and dose-dependent.
The correct answer is A
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